F51.0 F32 F33 F40 F41
Conditions
Interventions
Group 1: Observational group – patients with non-organic insomnia (ICD-10: F51.0)
no intervention, retrospective analysis of clinical polysomnographic and psychometric data.
Group 2: Observational group – patients with a depressive episode or recurrent depressive disorder (ICD-10:
no intervention, retrospective analysis of clinical polysomnographic and psychometric data.
Group 3: Observational group – patients with phobic or other anxiety disorders (ICD-10: F40.x, F41.x)
no intervention, retrospective analysis of clinical polysomnographic and psychometric data.
Group 4: Healthy control group
no intervention, retrospective analysis of polysomnographic and psychometric data.
Sponsors
Universitätsklinikum Freiburg, Klinik für Psychiatrie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of one of the following disorders according to ICD-10: o Non-organic insomnia (F51.0) o Phobic or other anxiety disorders (F40.x, F41.x) o Depressive episode or recurrent depressive disorder (F32.x, F33.x)
Exclusion criteria
Exclusion criteria: • History of another sleep disorder (e.g., sleep apnea syndrome, restless legs syndrome [RLS], periodic limb movements during sleep [PLMS], REM sleep behavior disorder [RBD], narcolepsy); exception: nightmare disorder • Use of medications affecting the central nervous system known to affect sleep (within the last two weeks prior to or during the sleep laboratory assessment) • Severe medical conditions that may affect sleep • Irregular sleep–wake schedule or shift work including night shifts within the last four weeks prior to the assessment • Pregnancy • Evidence of PLMS with an arousal index > 5 events/hour or apnea index > 5 events/hour • Severe or unstable psychiatric comorbidities that may affect sleep, including organic and symptomatic mental disorders (ICD-10: F00–F09), substance use disorders (ICD-10: F10–F19), as well as schizophrenia, schizotypal, and delusional disorders (ICD-10: F20–F29)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of sleep macro- and microstructure between diagnostic groups and healthy controls. The analysis is based on routine polysomnographic data and includes: •Sleep continuity (sleep duration, sleep efficiency, sleep latency, wake time after sleep onset, number of awakenings) •Sleep architecture (distribution of sleep stages: Wake, NREM1–3, REM) •REM parameters (REM latency, REM duration, REM density) •EEG microstructure (spectral analysis of power in the frequency bands Delta, Theta, Alpha, Sigma, Beta, Gamma) | — |
Secondary
| Measure | Time frame |
|---|---|
| Associations between the primary outcomes (polysomnographic sleep parameters) and the results of psychometric self-report questionnaires within and across groups: • Insomnia Severity Index (ISI) • Beck Depression Inventory (BDI) • Pittsburgh Sleep Quality Index (PSQI) • State-Trait Anxiety Inventory (STAI) | — |
Countries
Germany
Contacts
Public ContactLukas Spille
Universitätsklinikum Freiburg, Klinik für Psychiatrie und Psychotherapie
Outcome results
None listed