Sex differences in immunity after allogeneic stem cell transplantation
Conditions
Interventions
Group 1: Patient recruitment will be conducted through the clinical database of the Department of Stem Cell Transplantation. Sample collection will take place after written informed consent at 6, 7, 8
Sponsors
Universitätsklinikum Hamburg-Eppendorf, Zentrum für Onkologie, Abt. für Stammzelltransplantation
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Capacity to provide written informed consent - 3 months after the first allogeneic stem cell transplantation - Absence of relapse of the underlying hematologic disease - No active graft-versus-host disease (GvHD)
Exclusion criteria
Exclusion criteria: - no capacity to provide written informed consent - relapse of underlying hematologic disease - active graft-versus-host disease (GvHD)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study is initially hypothesis-generating and exploratory in nature. It is conceivable that immune cells from female donors, which may be more effective due to genetic factors, elicit stronger immune responses when exposed to the hormonal environment of male recipients. Conversely, immune cells from male donors may induce weaker immune responses in female patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Generation of new hypotheses for more detailed analyses of specific cell populations or proteins | — |
Countries
Germany
Contacts
Public ContactFrancis Ayuk
Universitätsklinikum Hamburg-Eppendorf, Zentrum für Onkologie, Abt. für Stammzelltransplantation
Outcome results
None listed