Intestinal permeability in liver cirrhosis K74.6
Conditions
Interventions
Group 1: All patients undergo a multisugar test. A single blood and urine sample is required from the test subjects for the examinations.
Once the participant has had sufficient time to consider parti
Sponsors
Medizinische Klinik III, Universitätsklinikum Aachen
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Cirrhosis of the liver, defined by clinical, laboratory, or histological criteria. 2. Ascites °2 or °3 within the last 7 days 3. Hospitalization at the time of study inclusion
Exclusion criteria
Exclusion criteria: 1. Hepatocellular carcinoma (HCC) outside Milan or extrahepatic malignancy 2. Pregnancy or breastfeeding 3. Condition after TIPS placement 4. Hypersensitivity or allergies to sucrose, rhamnose, sucralose, erythritol, or lactulose. 5. Hereditary fructose intolerance 6. Presence of an existing or concomitant disease or general health condition that, in the opinion of the investigator, poses an unacceptable risk for participation in the study 7. Lactulose treatment within the last 72 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Evidence of a significantly higher PV-1 concentration in patients with an elevated IP index (>median) compared to patients with a lower IP index (=median) 2. Transplant-free 90-day survival rate depending on the serum concentration of PV-1 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Occurrence of spontaneous bacterial peritonitis within 90 days 2. Occurrence of hospitalizations within 90 days 3. Occurrence of renewed decompensation within 90 days | — |
Countries
Germany
Contacts
Public ContactTony Bruns
Medizinische Klinik III, Universitätsklinikum Achen
Outcome results
None listed