The Z-Project includes adult patients with a broad range of psychiatric disorders. The primary focus is on affective disorders (particularly major depressive disorder) and anxiety or stress-related disorders. To enable a transdiagnostic network perspective, additional diagnostic groups are also eligible, including: Depressive disorders (current or remitted major depressive episodes) Anxiety disorders (e.g. generalized anxiety disorder, panic disorder, social anxiety disorder) Trauma- and stre
Conditions
Interventions
Group 1: Patients with mental disorders and healthy controls:
The Z-Project includes adult patients with primary diagnoses of depression, anxiety disorders or schizophrenia spectrum disorders, as well
Sponsors
Klinische Psychologie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: - Patients: Age 18–70 years DSM-5 diagnosis of a mental disorder (e.g. depressive disorders, anxiety disorders, PTSD, OCD, schizophrenia spectrum) Clinical stability (no acute suicidality, mania, or psychotic crisis) Sufficient German language skills and ability to provide informed consent Willingness to participate - Healthy controls: Age 18–70 years No current or past psychiatric disorder (according to mini DIPS) No current psychotropic medication Willing to participate
Exclusion criteria
Exclusion criteria: Organic brain disorders or neurological conditions (e.g., epilepsy, dementia, multiple sclerosis) Severe cognitive impairment or lack of capacity to provide informed consent Insufficient proficiency in the German language Significant, non-correctable impairments in hearing or vision
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the characterization of dynamic network structures of psychological symptoms, psychological processes, and neurobiological markers over a period of three weeks. This includes the assessment and modeling of symptom networks based on Ecological Momentary Assessment (EMA) data and their association with structural and functional MRI as well as EEG data obtained during the baseline assessment. During the smartphone-based EMA period of 21 days, assessments are conducted every two hours throughout the day, resulting in a total of five measurement points per day. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include: The predictive value of baseline MRI and EEG parameters for subsequent changes in individual network dynamics. Concordance between clinician-rated symptoms and self-reported EMA symptom data. Sex- and diagnosis-specific differences in network centrality measures and their temporal stability. Added predictive and explanatory value of speech-based features (baseline speech task and daily recordings) for EMA-derived networks. Transdiagnostic comparisons of network structures across depression, anxiety disorders, schizophrenia spectrum disorders, and healthy controls. | — |
Countries
Germany
Contacts
Public ContactWinfried Rief
Klinische Psychologie und Psychotherapie
Outcome results
None listed