I50.0 I50.1 J84.1 J44.9
Conditions
Interventions
Group 1: In patients who have undergone heart or lung transplants, the concentration of immunoglobulin M (IgM) in serum is determined at a maximum of 17 points in time (before surgery, immediately aft
Sponsors
Universitätsklinikum Essen, Klinik für Thorax- und Kardiovaskuläre Chirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with terminal heart and/or lung failure who are receiving an isolated heart transplant or an isolated lung transplant - Age = 18 years - Written informed consent from the patient
Exclusion criteria
Exclusion criteria: - Age < 18 years - Lack of consent - Combined procedure (multiple organ transplant) - Re-transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of clinically relevant immunoglobulin M deficiency (immunoglobulin M serum concentration < 0.8 g/L) | — |
Secondary
| Measure | Time frame |
|---|---|
| - MACCE (major adverse cardiac and cerebrovascular event), defined as hospital mortality, myocardial infarction, reoperation/reintervention, stroke, occurrence of sepsis/SIRS) - Postoperative serum concentration of calcineurin inhibitors (especially tacrolimus) - Primary graft dysfunction (ISHLT definition for heart and lung transplantation) - Acute rejection (ISHLT definition for heart and lung transplantation) | — |
Countries
Germany
Contacts
Public ContactMoritz B. Immohr
Universitätsklinikum Essen, Klinik für Thorax- und Kardiovaskuläre Chirurgie
Outcome results
None listed