Patients with Esophageal Carcinoma undergoing Minimally Invasive Ivor Lewis Esophagectomy with or without intraoperative Endoscopic Pylorus Balloon Dilatation: A Randomized Controlled Trial Investigating the Benefits of Intraoperative endoscopic Pylorus Dilatation

Patients with Esophageal Carcinoma undergoing Minimally Invasive Ivor Lewis Esophagectomy with or without intraoperative Endoscopic Pylorus Balloon Dilatation: A Randomized Controlled Trial Investigating the Benefits of Intraoperative endoscopic Pylorus Dilatation - WIDE Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00038237

Enrollment

116

Registered

2025-10-24

Start date

2025-12-23

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delayed gastric conduit emtpying (DGCE) Diagnosis Code, OPS-Code: 5-429.7 K31.8 C15

Interventions

Group 1: Intervention (with additional intraoperative endoscopic balloon dilatation) Group 2: Control (Standard procedure without additional intervention)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age >18 years - Histologically confirmed esophageal cancer - Planned surgical resection in curative intent as a minimally invasive Ivor Lewis procedure - Provided informed consent

Exclusion criteria

Exclusion criteria: - Prior esophageal or gastric resection - Non-curative intent of surgery - ASA Score V - Patients lacking capacity to provide informed consent

Design outcomes

Primary

Measure	Time frame
- Incidence of early DGCE in postoperative course (after 5 and 10 days, measured using radiological and clinical parameters)	—

Secondary

Measure	Time frame
- Incidence of late DGCE (after more than 14 days postoperatively) - Rates of anastomotic leak - Complication rates using Clavien Dindo classification - Hospital stays in days - Time to first bowel movement - Time to first solid food intake - Postoperative Quality of life (assessed with the EORTC QLQ-OES18 questionnaire)	—

Countries

Switzerland

Contacts

Public ContactMarko Kraljevic

Clarunis Universitäres Bauchzentrum Basel

marko.kraljevic@clarunis.ch061 777 7508

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026