Comparison of methods for plasma protein binding of anti-infectives using NMR and HPLC

Comparison of methods for plasma protein binding of anti-infectives using NMR and HPLC - FU-NMR-HPLC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038228

Enrollment

100

Registered

2025-10-24

Start date

2025-10-01

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Basic science, infectious diseases / pharmacology

Interventions

Group 1: A method comparison between qNMR and HPLC is performed using residual material samples from routine tests to investigate the feasibility of measuring the free concentration of piperacillin di

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: ICU stay Piperacillin therapy Routine blood draws with residuals available

Exclusion criteria

Exclusion criteria: n/a

Design outcomes

Primary

Measure	Time frame
Agreement of free concentrations of piperacillin	—

Secondary

Measure	Time frame
Bland Altman Analysis	—

Countries

Germany

Contacts

Public ContactAlexander Dejaco

Universitätsklinikum Regensburg, Klinik für Anästhesiologie

alexander.dejaco@ukr.de+4994194417515

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026