Menstrual migraine
Conditions
Interventions
Group 1: 20 women with menstrual or menstrual-associated migraine aged between 18 and 45 as well as 20 age-matched healthy women can participate. Participation involves completing online questionnaire
Sponsors
Hochschule Coburg
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Migraine group: • Self-reported regular cycle (approx. 26–34 days) • Medical diagnosis of purely menstrual or menstrual-associated migraine, with or without aura, diagnosed according to ICHD-3 (International Classification of Headache Disorders, 3rd edition, https://ichd-3.org/de) • Sufficient knowledge of German to answer the questionnaires • Written consent to participate in the study and data collection (via scan) • Non-fulfilment of one or more exclusion criteria Control group: • Self-reported regular cycle (approx. 26-34 days) • Sufficient knowledge of German to answer the questionnaires • Written consent to participate in the study and data collection (via scan) • Failure to meet one or more exclusion criteria
Exclusion criteria
Exclusion criteria: Migraine group: • Headache disorders other than migraine, with the exception of tension headaches on fewer than 2 days within the last month prior to screening • Special migraine therapy • Use of hormone preparations within the last two months prior to screening • Gynaecological, psychiatric or neurological conditions that are being treated medically • Pregnancy or breastfeeding Control group: • Migraine or other headache disorders, with the exception of tension headaches, on fewer than 2 days within the last month prior to screening • Use of hormone preparations within the last two months prior to screening • Gynaecological, psychiatric or neurological conditions that are being treated medically • Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Group comparison of alpha-CGRP concentrations in menstrual blood and saliva collected on the first day of menstruation | — |
Secondary
| Measure | Time frame |
|---|---|
| Group comparison of the following parameters: - Amylin, PACAP-38, estradiol, prostaglandin (PGE2) in menstrual blood and saliva samples from the first day of menstruation. - HIT-6 – headache impact test - SF-12 – short form 12 - DASS – depression-anxiety-stress scale - PSS-10 – perceived stress - Headache calendar of the German Headache Society - PANAS – positive and negative affect schedule | — |
Countries
Germany
Contacts
Public ContactJennifer Bohr
Hochschule Coburg
Outcome results
None listed