I50.1
Conditions
Interventions
Group 1: Quantification of splanchnic blood volume among the three predefined cohorts in routine cardiovascular MRI: After detailed verbal information and provision of the written patient-information
Sponsors
Herzzentrum Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age = 18 years Written informed consent Scheduled for a clinically indicated contrast-enhanced cardiovascular MR that meets one of the three cohort definitions above
Exclusion criteria
Exclusion criteria: Standard MR contraindications (ferromagnetic implants, severe claustrophobia, etc.) Contraindication to gadolinium contrast (eGFR < 30 mL/min/1.73 m² or prior severe allergic reaction) Hemodynamic instability requiring inotropic support or mechanical heart assistance Inability to give informed consent Pregnancy or lactation Participation in another clinical trial with an investigational device or drug that could interfere with the outcomes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean difference in splanchnic blood volume among the three predefined cohorts (patients without diastolic dysfunction, patients with diastolic dysfunction grade II and patients with diastolic dysfunction grade III/IV) | — |
Secondary
| Measure | Time frame |
|---|---|
| Echocardiographic correlation: Association between SBV and key TTE parameters (e.g., E/e' ratio, tricuspid-regurgitation velocity) Exploratory correlations between SBV and routine clinical measures (e.g., NYHA class, blood pressure, body-mass index) as well as standard laboratory values (e.g., NTproBNP) Inter-/Intraobserver variability of SBV | — |
Countries
Germany
Contacts
Public ContactCharlotte Wolff
Herzzentrum Leipzig
Outcome results
None listed