Determination of the impact of cow’s milk on pro- and anti-inflammatory immune processes and the clinical presentation in patients with acne vulgaris.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00038179

Enrollment

Registered

2025-11-25

Start date

2026-02-15

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

L70.0

Interventions

Group 1: Upon inclusion in the study, a blood sample will be taken, during which 40 ml of whole blood and 10 ml of serum will be collected from the same venipuncture. We will analyze the blood for imm

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Acne vulgaris

Exclusion criteria

Exclusion criteria: -Proven lactose intolerance -Proven gluten intolerance

Design outcomes

Primary

Measure	Time frame
• Analysis of milk-reactive antibodies in peripheral blood at baseline using enzyme-linked immunosorbent assay (ELISA) to detect and quantify pre-existing milk-specific humoral immune responses. • Assessment of the impact of cow’s milk consumption on pro- and anti-inflammatory immune responses in peripheral blood, depending on the presence or absence of a milk-specific immune reactivity at baseline and after 8 and 12 weeks of intervention. For this purpose, a detailed immunophenotyping of B- and T-cell populations will be performed using flow cytometry (FACS).	—

Measure

Time frame

• Analysis of milk-reactive antibodies in peripheral blood at baseline using enzyme-linked immunosorbent assay (ELISA) to detect and quantify pre-existing milk-specific humoral immune responses. • Assessment of the impact of cow’s milk consumption on pro- and anti-inflammatory immune responses in peripheral blood, depending on the presence or absence of a milk-specific immune reactivity at baseline and after 8 and 12 weeks of intervention. For this purpose, a detailed immunophenotyping of B- and T-cell populations will be performed using flow cytometry (FACS).

—

Secondary

Measure	Time frame
• Level of milk-specific antibody titers before and after cow’s milk consumption • Change in the percentage distribution of pro- and anti-inflammatory immune cell populations before and after cow’s milk consumption • Change in insulin-like growth factor 1 (IGF-1) levels before and after cow’s milk consumption • Change in acne severity according to the “Severity Acne Scale” by Hayashi et al. (2008) before and after cow’s milk consumption	—

Measure

Time frame

• Level of milk-specific antibody titers before and after cow’s milk consumption • Change in the percentage distribution of pro- and anti-inflammatory immune cell populations before and after cow’s milk consumption • Change in insulin-like growth factor 1 (IGF-1) levels before and after cow’s milk consumption • Change in acne severity according to the “Severity Acne Scale” by Hayashi et al. (2008) before and after cow’s milk consumption

—

Countries

Germany

Contacts

Public ContactStefanie Kürten

Universitätsklinikum Bonn

stefanie.kuerten@uni-bonn.de+49 228 287 62642

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026