Impact of Inspiration Time in the Respiratory Cycle on Airway Mechanics and Homogeneity of Lung Ventilation in Premature Infants <34 weeks - a Pilot Study

Impact of Inspiration Time in the Respiratory Cycle on Airway Mechanics and Homogeneity of Lung Ventilation in Premature Infants <34 weeks - a Pilot Study - ShortTI

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00038155

Enrollment

Registered

2025-10-14

Start date

2026-02-18

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory mechanics and homogeneity of lung ventilation

Interventions

Group 1: Long inspiratory times vs. short inspiratory times. Over a period of 12 minutes, different inspiratory times (0.1-0.4s) are set and the breathing mechanics are assessed via intratidal respira

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. gestational age < 34 weeks gestation 2. invasive ventilation

Exclusion criteria

Exclusion criteria: 1. severe congenital pulmonary or cardiac malformations 2. chromosomal abnormalities 3. severe ventilatory instability

Design outcomes

Primary

Measure	Time frame
• Influence of inspiratory time on transpulmonary pressure • Influence of inspiratory time on homogeneity of lung ventilation (EIT)	—

Secondary

Measure	Time frame
• Influence of inspiratory time on compliance and resistance • Influence of inspiratory time on the necessary inspiratory pressure at constant tidal volume • Determination of variability in time constants • Stability of ventilation (CO2 and SpO2 fluctuations)	—

Countries

Germany

Contacts

Public ContactMartin Kuntz

Universitätsklinikum Freiburg, Klinik für Kinder- und Jugendmedizin

martin.kuntz@uniklinik-freiburg.de+4976127043000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026