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New biomarkers in patients with acute and chronic heart failure

New biomarkers in patients with acute and chronic heart failure - ZKAM-HF1

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00038114
Enrollment
119
Registered
2025-10-10
Start date
2025-10-10
Completion date
Unknown
Last updated
2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

compensated heart failure, stable heart failure

Interventions

Group 1: Patients who were hospitalized at the University Medical Center Mannheim (UMM) due to acute decompensation of their heart failure Group 2: Patients in a recompensated state of their heart fai

Sponsors

Universitätsmedizin Mannheim UMM
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who meet the criteria for the diagnosis of chronic heart failure, provide informed consent to participate in the study, and demonstrate willingness to attend follow-up visits at the heart failure outpatient clinic.

Exclusion criteria

Exclusion criteria: -Patients unable to provide informed consent or under legal guardianship -Patients under 18 years of age -Pregnant women -Advanced malignant disease -Liver cirrhosis, Child C -Patients requiring dialysis

Design outcomes

Primary

MeasureTime frame
- Cardiovascular death: defined as death due to acute coronary syndrome, ventricular fibrillation, or heart failure -Time to first unplanned hospitalization due to heart failure

Secondary

MeasureTime frame
-Decrease in quality of life over time -Increase in NT-proBNP levels over time -Outpatient intensification of heart failure medication therapy -Reduction in walking distance in the 6-minute walk test over time

Countries

Germany

Contacts

Public ContactThomas Helbing

Universitätsmedizin Mannheim Zentrum für kardiovaskuläre Akuterkrankungen

thomas.helbing@umm.de+4916097346517

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026