Evaluation of the Effect of Intraoperatively Administered, Laparoscopically Visualized Autonomic Nerve Block of the Celiac Plexus (L-PCB) in Roux-en-Y Gastric Bypass Surgery – A Prospective, Randomized, Controlled Pilot Study

Evaluation of the Effect of Intraoperatively Administered, Laparoscopically Visualized Autonomic Nerve Block of the Celiac Plexus (L-PCB) in Roux-en-Y Gastric Bypass Surgery – A Prospective, Randomized, Controlled Pilot Study - L-PCB

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00038102

Enrollment

Registered

2025-10-10

Start date

2025-09-30

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Stomach

Interventions

Group 1: Intervention: Laparoscopically guided autonomic nerve block of the celiac plexus (L-PCB) using 30 ml of ropivacaine 0.75% (225 mg). Group 2: Control group: Local wound infiltration with 30 ml

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • >18 years of age • ASA physical status I–III

Exclusion criteria

Exclusion criteria: • Language barrier • Cognitive impairments preventing the patient from understanding the nature, scope, and significance of the study • GFR 60

Design outcomes

Primary

Measure	Time frame
Assessment of patients’ pain intensity using the Numerical Rating Scale (NRS) until discharge (no later than postoperative day 3).	—

Secondary

Measure	Time frame
• Morphine milligram equivalents (MME) • Consumption of metamizole and paracetamol • Return of gastrointestinal function (time until tolerance of 1 liter of fluids) • Vomiting, salivation, hiccups • Postoperative mobility • Successful performance of the L-PCB • L-PCB–related adverse events • Overall complications assessed using the Comprehensive Complication Index (CCI) • Readmission within 30 days after surgery • Length of postoperative hospital stay • Intraoperative analgesia • Patient satisfaction • Depression Anxiety Stress Scales (DASS) questionnaire • QUIPS (Quality Improvement in Postoperative Pain Therapy) questionnaire on postoperative day 1 at 8 a.m. • Noxiousness Level (NOS)	—

Measure

Time frame

• Morphine milligram equivalents (MME) • Consumption of metamizole and paracetamol • Return of gastrointestinal function (time until tolerance of 1 liter of fluids) • Vomiting, salivation, hiccups • Postoperative mobility • Successful performance of the L-PCB • L-PCB–related adverse events • Overall complications assessed using the Comprehensive Complication Index (CCI) • Readmission within 30 days after surgery • Length of postoperative hospital stay • Intraoperative analgesia • Patient satisfaction • Depression Anxiety Stress Scales (DASS) questionnaire • QUIPS (Quality Improvement in Postoperative Pain Therapy) questionnaire on postoperative day 1 at 8 a.m. • Noxiousness Level (NOS)

—

Countries

Germany

Contacts

Public ContactSusanne Blank

Chirurgische Klinik der Universitätsmedizin Mannheim (Universität Heidelberg)

susanne.blank@umm.de0621-383-2225

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026