G20 G12
Conditions
Interventions
Group 1: In this prospective study, we aim at mapping the electrophysiological architecture of the motor cortex using non-invasive Magnetoencephalography (MEG). Brain activity is acquired using MEG du
Sponsors
Universitätsklinikum Düsseldorf
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Healthy participants (Study Part 1): No neurological, psychiatric, or internal medical disorders Age > 18 years Right-handed: Edinburgh Handedness Inventory Test No cognitive impairment: Montreal Cognitive Assessment (MoCA) > 25 No motor deficits: UPDRS III = 1 Capacity to provide informed consent Understanding of the study procedures and written informed consent to participate Patients with Parkinson’s disease (Study Parts 2 and 3): Diagnosis of Parkinson’s disease Treatment with deep brain stimulation (DBS) using directional electrodes Either completion of follow-up visits approx. 3 months and 12 months after DBS surgery or consent to participate in follow-up visits approx. 3 months and 12 months after DBS surgery (part of routine clinical care at our center) Age > 40 years Capacity to provide informed consent Understanding of the study procedures and written informed consent to participate Patients with ALS (Study Part 4): Age > 18 years Clinically confirmed diagnosis of ALS according to the Gold Coast criteria Capacity to provide informed consent Understanding of the study procedures and written informed consent to participate
Exclusion criteria
Exclusion criteria: Healthy participants: Parkinson’s disease or other severe neurological, internal medical, or psychiatric disorders Reduced cognitive abilities: MoCA < 25 Implants causing significant ferromagnetic artifacts (which would make MEG analysis impossible), such as tattoos containing metal, pacemakers, defibrillators, implanted pumps, and other interfering metallic implants Large head circumference preventing comfortable positioning within the MEG helmet Claustrophobia Patients with Parkinson’s disease: Additional severe neurological, internal medical, or psychiatric disorders Reduced cognitive abilities: MoCA < 25 Implants causing significant ferromagnetic artifacts (which would make MEG analysis impossible), such as tattoos containing metal, pacemakers, defibrillators, implanted pumps, and other interfering metallic implants, with the exception of the DBS system Large head circumference preventing comfortable positioning within the MEG helmet Claustrophobia Patients with ALS: Additional severe neurological, internal medical, or psychiatric disorders Implants causing significant ferromagnetic artifacts (which would make MEG analysis impossible), such as tattoos containing metal, pacemakers, defibrillators, implanted pumps, and other interfering metallic implants Large head circumference preventing comfortable positioning within the MEG helmet Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this study is to map the functional organization of the motor cortex electrophysiologically using non-invasive magnetoencephalography (MEG). The specific objectives are: 1.) To map the functional electrophysiological architecture of M1 in healthy humans based on movement-associated neural activity. | — |
Secondary
| Measure | Time frame |
|---|---|
| 2.) To investigate changes in the functional electrophysiological architecture of M1 in Parkinson’s disease as a model disorder of the extrapyramidal motor system, and to examine the effects of deep brain stimulation on this architecture. 3.) To conduct an exploratory analysis of the functional electrophysiological architecture of M1 in individuals with a disease of the cortico-motoneuronal system (ALS). | — |
Countries
Germany
Contacts
Public ContactBahne Tenge-Bahners
Universitätsklinikum Düsseldorf
Outcome results
None listed