Parkinson's Disease G20
Conditions
Interventions
Group 1: Clinical population: 36 people with less than 2 years of clinical Parkinson's Disease (PD) diagnosis according to the MDS clinical diagnostic criteria (including male and females).
All study
Sponsors
Uniklinik Köln, Klinik für Neurologie und Klinik für Nuklearmedizin
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Clinical group: ? Ability to give written consent to participate ? Diagnosis according to the MDS clinical diagnostic criteria by Postuma et al. (2015) ? Clinical symptoms < 3 years ? Right-handed ? DaT-SPECT within 3 months prior to inclusion into the study Control group: ? Ability to give written consent to participate ? Right-handed
Exclusion criteria
Exclusion criteria: ? Indication of cognitive deficits (MoCA 5) ? Significant comorbidities ? Contraindications for MRI ? No consent ? Chronic neurological disorders other than PD ? Hoehn and Yahr scale of >= 3 ? Pregnancy or breast feeding ? Wounds at the ear ? Known anatomical anomalies of the vagus nerve ? Have no insulin resistance or other metabolic disturbances
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor motivation measured at T1-T3 with an incentivised force task (adapted from LeBouc, 2016)[https://doi.org/10.1523/JNEUROSCI.3078-15.2016]. Motor performance measured with the UPDRS-III. | — |
Secondary
| Measure | Time frame |
|---|---|
| Imaging markers of disease progression (T1). Performance in an incentivized yank task during fMRI (T1). Cognitive performance in a computerized dual task (T1). Self reported life style factors (T3). | — |
Countries
Germany
Contacts
Public ContactThilo van Eimeren
Uniklinik Köln, Klinik für Neurologie und Klinik für Nuklearmedizin
Outcome results
None listed