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Reactivity to drug associated stimuli in vivo versus in virtual reality in heroin dependent patients in opioid maintenance treatment

Reactivity to drug associated stimuli in vivo versus in virtual reality in heroin dependent patients in opioid maintenance treatment

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00038029
Enrollment
68
Registered
2025-10-28
Start date
2025-11-21
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F11.2 Z51.83

Interventions

Group 1: Cue exposure with heroin and injection equipment in virtual reality Group 2: In vivo cue exposure with heroin replica (light brown powder) and injection equipment

Sponsors

Zentralinstitut für Seelische Gesundheit, Klinik für Abhängiges Verhalten und Suchtmedizin
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: • diagnosis F11.2 and current opioid maintenance treatment • intravenous heroin use in the anamnesis • ability to give consent • participants are to be examined after taking their opioid substitute

Exclusion criteria

Exclusion criteria: • acute intoxication • psychotic symptoms or symptoms of severe depression • severe somatic disorders • known intolerance to rapidly flickering visual stimuli, which occur very rarely in certain forms of epilepsy (identifiable through reported similar problems during past cinema visits) • ametropia of more than three dioptres and unability to wear contact lenses • pregnancy or breast feeding • inability to give consent

Design outcomes

Primary

MeasureTime frame
self-reported craving on a visual analogue scale

Secondary

MeasureTime frame
• physiological measures: skin conductivity and heart activity • positive and negative affect (PANAS scales)

Countries

Germany

Contacts

Public ContactKatharina Eidenmüller

Zentralinstitut für Seelische Gesundheit, Klinik für Abhängiges Verhalten und Suchtmedizin

katharina.eidenmueller@zi-mannheim.de+4962117033827

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026