MENINTplus – Prospective Register Study on Meningitis and Encephalitis in Intensive Care Units in Germany

MENINTplus – Prospective Register Study on Meningitis and Encephalitis in Intensive Care Units in Germany - MENINTplus

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037869

Enrollment

300

Registered

2025-10-08

Start date

2025-08-01

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G00-G09

Interventions

Group 1: Patients with infections of the central nervous system who are treated in intensive care units in Germany.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Assignment to at least one of the following diagnostic groups possible: - Bacterial CNS infection: Acute bacterial meningitis, subacute or chronic bacterial meningitis, bacterial brain abscess, nosocomial ventriculitis - Viral CNS infections: Viral encephalitis caused by herpesviruses, viral encephalitis caused by flaviviruses, viral encephalitis caused by other viruses (only if pathogen detected) - Fungal infections of the central nervous system - Infections of the central nervous system with other pathogens (only if pathogen detected)

Exclusion criteria

Exclusion criteria: Age <18 No clear assignment of the diagnosis to the specified diagnosis groups possible

Design outcomes

Primary

Measure	Time frame
Prospective data collection on pathogen-related infections of the central nervous system in Germany during hospitalization and 6–12 months after discharge.	—

Secondary

Measure	Time frame
Complications during hospitalization - Epileptic seizures - Hydrocephalus - Multiple organ failure - Cerebral vasculopathy - Autoimmune encephalitis Long-term complications - Hearing impairment - Neurocognitive deficits - Focal neurological deficits Treatment aspects - Time to diagnosis - Time to initiation of empirical and/or targeted therapy - Type, duration, and discontinuation rates of anti-infective therapy Care parameters / Health services research - Length of ICU and hospital stay - Discharge destination - Impact of treatment strategies on outcome Epidemiological trends - Incidence and prevalence per year/region - Changes in pathogen distribution and resistance patterns Biomarkers / Diagnostics - Predictors of poor outcome in the early phase - Diagnostic accuracy of CSF/serum parameters Patient-centered endpoints - Quality of life in follow-up (SF-36) - Ability to work / social reintegration	—

Measure

Time frame

Complications during hospitalization - Epileptic seizures - Hydrocephalus - Multiple organ failure - Cerebral vasculopathy - Autoimmune encephalitis Long-term complications - Hearing impairment - Neurocognitive deficits - Focal neurological deficits Treatment aspects - Time to diagnosis - Time to initiation of empirical and/or targeted therapy - Type, duration, and discontinuation rates of anti-infective therapy Care parameters / Health services research - Length of ICU and hospital stay - Discharge destination - Impact of treatment strategies on outcome Epidemiological trends - Incidence and prevalence per year/region - Changes in pathogen distribution and resistance patterns Biomarkers / Diagnostics - Predictors of poor outcome in the early phase - Diagnostic accuracy of CSF/serum parameters Patient-centered endpoints - Quality of life in follow-up (SF-36) - Ability to work / social reintegration

—

Countries

Germany

Contacts

Public ContactKonstantin Pusl

Neurologische Klinik und Poliklinik, Klinikum der LMU München - Großhadern

konstantin.pusl@med.uni-muenchen.de089 4400 73690

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026