Individuals with Parkinson's disease, group of healthy older individuals
Conditions
Interventions
Group 1: Transcutaneous auricular vagus nerve stimulation (taVNS), true stimulation (3 seconds of stimulation and 12 seconds of pause over a total duration of 10 minutes during pupil measurement) in b
Sponsors
Universitätsklinik für Neurologie, Evangelisches Krankenhaus Oldenburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - German as native language or adequate German language skills - Adults (= 18) - Normal cognitive screening (MoCA test > 21 points)
Exclusion criteria
Exclusion criteria: - Previous neurological or psychiatric conditions (except Parkinson's disease) - Relevant eye conditions (including previous eye surgery, glaucoma, pseudoexfoliation syndrome at the edge of the pupil or on the lens, corneal disease, nonspherical pupils, relevant anisocoria), diabetes mellitus - Use of centrally acting medications (except for Parkinson's medication) - Multifocal contact lenses, reflective glasses, or glasses with lots of shiny decorations (if these can be taken off/removed and the visual acuity is sufficient to be able to fixate on the fixation cross, the test subjects can be included and the measurement will take place without the visual aid)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference between pupil dilation before (baseline) and after taVNS (or sham stimulation) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Reaction time during cognitive tasks (TAP-M) - REM sleep disorder (IRBD-SSS-PT) | — |
Countries
Germany
Contacts
Public ContactKarsten Witt
Universitätsklinik für Neurologie, Evangelisches Krankenhaus Oldenburg
Outcome results
None listed