Effect of Pericapsular Nerve Group (PENG) Block on Postoperative Pain After Elective Total Hip Arthroplasty – A Prospective, Randomized, Double-Blind Trial

Effect of Pericapsular Nerve Group (PENG) Block on Postoperative Pain After Elective Total Hip Arthroplasty – A Prospective, Randomized, Double-Blind Trial - PENG-THA

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037861

Enrollment

168

Registered

2025-09-22

Start date

2025-09-22

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M16.1

Interventions

Group 1: 10 ml Ropivacaine 0.375% (PENG block) + 5 ml Bupivacaine 0.5% (LFCN block) Group 2: 20 ml Ropivacaine 0.375% (PENG block) + 5 ml Bupivacaine 0.5% (LFCN block) Group 3: 20 ml Ropivacaine 0.375

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: ASA physical status I–III Scheduled elective total hip arthroplasty under general anesthesia Written informed consent to participate

Exclusion criteria

Exclusion criteria: Known allergy to amide-type local anesthetics Pregnancy or breastfeeding Body mass index (BMI) 40 kg/m² Dementia, delirium, or other cognitive impairment Anticoagulation without bridging Chronic opioid use (>60 mg morphine equivalent daily for =6 days) Systemic infection or local infection at puncture site Severe hepatic insufficiency or acute renal failure

Design outcomes

Primary

Measure	Time frame
Numeric Rating Scale (NRS) pain score at rest 4 hours postoperatively	—

Secondary

Measure	Time frame
NRS pain scores at additional predefined time points (T0, T1, T2, T3, T4, T5, T6 – up to 24 h postoperatively) Total opioid consumption within 24 h postoperatively (expressed as morphine equivalents, according to the LONTS guideline conversion tool) Motor function of the quadriceps femoris muscle measured by the Medical Research Council (MRC) scale 4 h postoperatively Incidence of block-related adverse events (e.g., vascular puncture, paresthesia, local anesthetic toxicity) Incidence of postoperative nausea and vomiting (PONV) at 4 h and 24 h Patient satisfaction at 24 h postoperatively (5-point Likert scale) Block success rate (defined as NRS reduction of >1 point 30 min after injection) Sensory loss of the lateral thigh for assessment of concomitant blockade of the lateral femoral cutaneous nerve (LFCN) at T0 + 10 min Physical activity during early postoperative period Cognitive performance measured by Montreal Cognitive Assessment (MoCA) test Clinical Frailty Scale (CFS)	—

Measure

Time frame

NRS pain scores at additional predefined time points (T0, T1, T2, T3, T4, T5, T6 – up to 24 h postoperatively) Total opioid consumption within 24 h postoperatively (expressed as morphine equivalents, according to the LONTS guideline conversion tool) Motor function of the quadriceps femoris muscle measured by the Medical Research Council (MRC) scale 4 h postoperatively Incidence of block-related adverse events (e.g., vascular puncture, paresthesia, local anesthetic toxicity) Incidence of postoperative nausea and vomiting (PONV) at 4 h and 24 h Patient satisfaction at 24 h postoperatively (5-point Likert scale) Block success rate (defined as NRS reduction of >1 point 30 min after injection) Sensory loss of the lateral thigh for assessment of concomitant blockade of the lateral femoral cutaneous nerve (LFCN) at T0 + 10 min Physical activity during early postoperative period Cognitive performance measured by Montreal Cognitive Assessment (MoCA) test Clinical Frailty Scale (CFS)

—

Countries

Germany

Contacts

Public ContactUlrich Frey

St Anna Hospital Herne

ulrich.frey@elisabethgruppe.de+4923259860

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026