Effect of PEEP during mechanical ventilation for radical prostatectomy on the endothelial and alveolar glycocylx

Effect of PEEP during mechanical ventilation for radical prostatectomy on the endothelial and alveolar glycocylx - GlycoPEEPPRE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037859

Enrollment

Registered

2025-09-08

Start date

2025-01-15

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilation Induced Lung Injury

Interventions

Group 1: In the "low PEEP" group, patients will be ventilated with a PEEP of 5 mbar throughout the entire operation. Group 2: In the "high PEEP" group, patients will be ventilated with a PEEP of 10 mb

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: elective robotic radical prostatectomy

Exclusion criteria

Exclusion criteria: Age < 18 ASA 4 patients' denial

Design outcomes

Primary

Measure	Time frame
Comparison of the two groups with regard to the difference in glycocalyx marker concentrations between the beginning (T0) and the end (T1) of mechanical ventilation.	—

Secondary

Measure	Time frame
Comparison of the two groups with regard to the Horovitz-Index between the beginning (T0) and the end (T1) of mechanical ventilation.	—

Countries

Austria

Contacts

Public ContactJoanna Baron

Barmherzigen Schwestern Krankenhaus Wien

joanna.baron@bhs.at+431599882122

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026