No desease / health problem is being investigated. Investigation of the influence of MCT and different carbohydrate sources on the metabolism of healthy subjects.
Conditions
Interventions
Group 1: Emulsified intervention drink consisting of water, flavoring, sweetener, medium-chain triglycerides (MCT) (0.3 g/kg body weight*), glucose (0.3 g/kg body weight).
*Adaptation to 0.4 g/kg body
Sponsors
FH Münster
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: - Normal body weight (BMI = 18.5–25.0)
Exclusion criteria
Exclusion criteria: - Pregnancy/breastfeeding - Presence of a serious/chronic illness with serious health impairments (e.g., cancer, cardiovascular disease, thyroid disorders, intestinal disorders) or acute illness at the time of examination - Known metabolic disorder (e.g., lipid metabolism disorder, type 1 or 2 diabetes mellitus) - Use of medication (exception: contraceptives) - Use of MCT within the past 4 weeks - Mental or linguistic limitations - Low carb or other diets with a permanent reduction in carbohydrate intake (EFSA: at least 45 En% KH) - Diagnosed eating disorders - Whole blood donation within the last 3 months and/or blood plasma donation within the last 4 weeks before the start of the study - Intolerance to sweeteners (e.g., cyclamate, thaumatin, aspartame) - Difficult/impossible venous blood collection due to anatomical conditions or other medical reasons (e.g., veins that are difficult to locate, fragile, or severely sclerotic) - Pronounced fear of blood collection or injections
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ß-hydroxybutyrate (ßHB; tmax) in venous blood, measured before the intervention (t0) and 30, 60, 120, 180, 240, and 300 minutes (t1 - t6) after the intervention. Blood is drawn using an indwelling venous catheter. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Body weight measured using body scales before the intervention days - Body height measured using a stadiometer before the intervention days - Body mass index (BMI) calculated from body weight and height before the intervention days - Body composition measured using bioelectrical impedance analysis (BIA) before the intervention days - Insulin, glucose, and essential/non-essential fatty acids in venous blood, measured before the intervention (t0) and 30, 60, 120, 180, 240, and 300 minutes (t1 - t6) after the intervention - Glucose in interstitial fluid via permanent glucose sensor, continuous measurement - Glucose and ßHB in capillary blood, measured before the intervention (t0) and 30, 60, 180, and 300 minutes (t1, t2, t4, t6) after the intervention. - Ketone bodies, leukocytes, nitrite, pH, protein, glucose, urobilinogen, bilirubin, blood in urine by collecting spontaneous urine and analyzing with urine strips between t0 and t6 - Resting energy expenditure (REE) and macronutrient proportions in energy metabolism via indirect calorimetry before the intervention days and once per intervention day | — |
Countries
Germany
Contacts
Public ContactTobias Fischer
FH Münster
Outcome results
None listed