Clinical efficacy of air-polishing with and without soft tissue curettage and the adjunctive application of biologics in the non-surgical treatment of patients with peri-implantitis – a multicenter randomized controlled trial

Clinical efficacy of air-polishing with and without soft tissue curettage and the adjunctive application of biologics in the non-surgical treatment of patients with peri-implantitis – a multicenter randomized controlled trial - Soft tissue curettage and biologics in the non-surgical peri-implantitis therapy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037779

Enrollment

Registered

2025-08-27

Start date

2025-09-29

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implantitis

Interventions

Group 1: Submucosal decontamination using ultrasonic and trehalose powder air-polishing (TPAP) Group 2: Submucosal decontamination using ultrasonic and trehalose powder air-polishing (TPAP) + soft tis

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Age: at least 18 years • Patients with at least one screw-type implant with peri-implantitis (progressive bone loss of =3 mm; PD = 6 mm, BOP and/or suppuration)

Exclusion criteria

Exclusion criteria: • Peri-implantitis therapy within the last 12 months • Suprastructure with an emergence profile that does not allow adequate instrumentation down to the bottom of the pocket • Insufficient mucosal thickness (visible transparency of the periodontal probe) • Use of local or systemic antibiotics within the last 4 months • Use of medications associated with the development of gingival overgrowth • Use of medications that affect bone metabolism (antiresorptives) • Systemic diseases known to interact with periodontal conditions or requiring prophylactic antibiotic coverage • General health risk due to increased bacteremia risk • Pregnancy

Design outcomes

Primary

Measure	Time frame
Changes in probing pocket depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP), assessed at 3 and 6 months after therapy compared to baseline using a pressure-calibrated periodontal probe.	—

Secondary

Measure	Time frame
Number of stable pockets (PD = 5 mm with at most one bleeding site) at 3 and 6 months post-treatment ("Avoidance of Surgery")	—

Countries

Germany, Romania, Slovenia

Contacts

Public ContactJamal M. Stein

Klinik für Zahnerhaltung, Parodontologie u. Präventive Zahnheilkunde, Universitätsklinikum Aachen

jstein@ukaachen.de+49 214 8088110

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026