Post-acute viral infectious syndromes in Berlin (PAIS Berlin): Structured cross-sectoral and interdisciplinary care

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037756

Enrollment

1050

Registered

2025-09-01

Start date

2026-02-16

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-acute viral infectious syndromes

Interventions

Group 1: Patients with post-acute viral infectious syndromes in Berlin who request for a healthcare appointment at an outpatient clinic in Charité and receive healthcare appointment will be observed f

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Appointment request at one of the participating outpatient clinics of Charité due to symptoms limiting daily life, persisting for more than 3 months, and not explained by other diagnoses 2. Sufficient German language skills to participate in a questionnaire-based study 3. Statutory health insurance coverage (GKV-insured) 4. Residence in the Berlin metropolitan region

Exclusion criteria

Exclusion criteria: 1. Lack of capacity to provide informed consent 2. Previous consultation at a PCN outpatient clinic or treatment within the last six months 3. Residence outside the Berlin metropolitan region 4. Privately insured or self-paying patients

Design outcomes

Primary

Measure	Time frame
Exploratory endpoints: Quality of life at baseline and after 3, 6, 9, 18 months (SF36, EQ-5D-5L) and patient satisfaction at baseline and after 3, 6, 9, 18 months (PSQ-18)	—

Secondary

Measure	Time frame
Exploratory endpoints: • Medical assessment of overall health and well-being at each appointment in the outpatient clinic during the PAIS Berlin study (VAS). • Changes in key symptoms between baseline, months 3, 6, 9, 12, and 18 (MLCSQ, PROM). • Changes in clinical findings at each appointment at the outpatient clinic during the PAIS Berlin study (activity level, psychological aspects, fatigue and exercise intolerance, memory impairment, shortness of breath, joint/muscle pain, neuropathy and myopathy, cardiological symptoms/POTS) • Change in subjective health status and well-being between baseline, months 3, 6, 9, 12, and 18 (EQ-5D-5L (VAS), MEHM, PROM). • Depression between baseline, months 3, 6, 9, 12, and 18 (PROM). • Changes in therapy (in further procedure/therapy recommendations), measured by data extraction from the clinical case files at each appointment in the outpatient clinic during the PAIS Berlin study. • Changes in understanding of the disease between baseline, months 3, 6, 9, 12, and 18 (IPQ-R). • Number of out of pocket over the counter medication and additional therapies paid for and remedies used between baseline, months 3, 6, 9, 12, and 18 and (patient reported) as well as number at each appointment in the outpatient clinic during the PAIS Berlin study (medical prescriptions in the medication plan). • Self-efficacy and coping between baseline, months 3, 6, 9, 12, and 18 (Questionnaire). • Healthcare utilization between baseline, months 3, 6, 9, 12, and 18 (Questionnaire). • Experiences and expectations of healthcare services and its delivery between baseline, months 3, 6, 9, 12, and 18 (Questionnaire).	—

Measure

Time frame

Exploratory endpoints: • Medical assessment of overall health and well-being at each appointment in the outpatient clinic during the PAIS Berlin study (VAS). • Changes in key symptoms between baseline, months 3, 6, 9, 12, and 18 (MLCSQ, PROM). • Changes in clinical findings at each appointment at the outpatient clinic during the PAIS Berlin study (activity level, psychological aspects, fatigue and exercise intolerance, memory impairment, shortness of breath, joint/muscle pain, neuropathy and myopathy, cardiological symptoms/POTS) • Change in subjective health status and well-being between baseline, months 3, 6, 9, 12, and 18 (EQ-5D-5L (VAS), MEHM, PROM). • Depression between baseline, months 3, 6, 9, 12, and 18 (PROM). • Changes in therapy (in further procedure/therapy recommendations), measured by data extraction from the clinical case files at each appointment in the outpatient clinic during the PAIS Berlin study. • Changes in understanding of the disease between baseline, months 3, 6, 9, 12, and 18 (IPQ-R). • Number of out of pocket over the counter medication and additional therapies paid for and remedies used between baseline, months 3, 6, 9, 12, and 18 and (patient reported) as well as number at each appointment in the outpatient clinic during the PAIS Berlin study (medical prescriptions in the medication plan). • Self-efficacy and coping between baseline, months 3, 6, 9, 12, and 18 (Questionnaire). • Healthcare utilization between baseline, months 3, 6, 9, 12, and 18 (Questionnaire). • Experiences and expectations of healthcare services and its delivery between baseline, months 3, 6, 9, 12, and 18 (Questionnaire).

—

Countries

Germany

Contacts

Public ContactLorena Dini

Charité – Universitätsmedizin Berlin

lorena.dini@charite.de+49 30 450 514 229

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026