Exploratory study in multiple dermatological diseases with a focus on optoacoustic imaging
Conditions
Interventions
Group 1: Patients with various dermatological diseases (e.g. psoriasis, eczema, lupus erythematosus, scleroderma, dermatomyositis, lichen planus, prurigo, autoimmune blistering dermatoses, chronic wou
Sponsors
Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients with inflammatory, autoimmune, neoplastic or metabolic skin diseases (e.g. psoriasis, eczema, lupus, scleroderma, dermatomyositis, lichen planus, prurigo, autoimmune blistering dermatoses, wounds, diabetes, naevi, melanoma, nail disorders). Optoacoustic control measurements on healthy skin areas of the same patients.
Exclusion criteria
Exclusion criteria: - Pregnancy and lactation - Psychiatric comorbidities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exploratory Optoacoustic parameters - Visualization of fine skin microvasculature - Vascular features - Distribution of melanin - Functionality of capillaries - Water and lipid content Comparison - Clinical skin findings - Disease severity scores (e.g., PASI, EASI, depending on disease) - Optoacoustic control measurements on healthy skin Correlation - Corneometry (skin hydration) - TEWL (transepidermal water loss) - OCT (epidermal thickness, vascular supply, skin roughness) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Image quality / technical feasibility (artifacts, reproducibility, limitations vs. OCT) - Functional tests (blood pressure cuff, heated coupling medium) - Combination with OCT, corneometry, TEWL - Development/validation of quantitative biomarkers (e.g., vessel density, blood volume) | — |
Countries
Germany
Contacts
Public ContactUlf Darsow
TUM Universtitätsklinikum
Outcome results
None listed