Non-invasive detection and characterization of cutaneous microvascular defects in patients with atherosclerotic cardiovascular disease using optoacoustic imaging

Non-invasive detection and characterization of cutaneous microvascular defects in patients with atherosclerotic cardiovascular disease using optoacoustic imaging - CVD-RSOM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037748

Enrollment

240

Registered

2025-08-22

Start date

2019-07-15

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25

Interventions

Group 1: RSOM measurements in patients diagnosed with atherosclerotic cardiovascular disease Group 2: RSOM measurements in healthy participants

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Group A: 120 patients diagnosed with atherosclerotic cardiovascular disease (coronary heart disease, carotid atherosclerosis, and peripheral arterial occlusive disease), regardless of age or gender. Group B: 120 age- and gender-matched healthy subjects with no evidence of cardiovascular disease.

Exclusion criteria

Exclusion criteria: a) Refusal to undergo the examination. b) Pregnancy. c) Heavily pigmented skin (leads to significant attenuation of the RSOM signal due to the presence of melanin in the skin). d) Documented or suspected light allergy, light intolerance, contact dermatitis, or particularly sensitive skin. e) Age under 18 years. f) Open or infected wounds at the measurement sites.

Design outcomes

Primary

Measure	Time frame
(A) Is RSOM technology suitable for detecting and quantifying structural and functional microvascular disorders in the skin of patients with atherosclerotic cardiovascular disease?	—

Secondary

Measure	Time frame
(B) How do RSOM parameters correlate with the severity of atherosclerotic cardiovascular disease and cardiovascular risk profile? (C) How do RSOM parameters correlate with the genetic profile of patients with cardiovascular disease? (D) How do the RSOM parameters correlate with the sonographic findings? (E) How do the RSOM parameters correlate with the O2C findings? (F) How are the RSOM parameters related to the laboratory values (if available)?	—

Measure

Time frame

(B) How do RSOM parameters correlate with the severity of atherosclerotic cardiovascular disease and cardiovascular risk profile? (C) How do RSOM parameters correlate with the genetic profile of patients with cardiovascular disease? (D) How do the RSOM parameters correlate with the sonographic findings? (E) How do the RSOM parameters correlate with the O2C findings? (F) How are the RSOM parameters related to the laboratory values (if available)?

—

Countries

Germany

Contacts

Public ContactUte Chambers

Lehrstuhl für Biologische Bildgebung, Technische Universität München

ute.chambers@tum.de+49 89 3187 43779

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026