Intensive Language-Action Therapy combined with Acceptance and Commitment Therapy for group-based transdisciplinary treatment of post-stroke depression and aphasia (SYNERGY)

Intensive Language-Action Therapy combined with Acceptance and Commitment Therapy for group-based transdisciplinary treatment of post-stroke depression and aphasia (SYNERGY) - SYNERGY II

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037667

Enrollment

Registered

2026-03-16

Start date

2026-03-30

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F06.3

Interventions

Group 1: Intervention group (immediate start): ILAT combined with ACT

3-week intensive intervention phase

frequency: 3 sessions per week, each lasting 2.5 hours per day (2 hours of ILAT, 0.5 hours of ACT)

total treatment dosage: 22.5 hours Group 2: Waiting-list control group (delayed start): ILAT combined with ACT

3-week waiting period, followed by 3-week intensive intervention phase

total treatment dosage: 22.5 hours

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) left-hemispheric cortical or subcortical ischemic or hemorrhagic event; (2) stroke occurred at least 6 months prior to study enrolment; (3) German as first native language; (4) right-handedness, as confirmed by the Oldfield Handedness Inventory; (5) diagnosis of aphasia with at least basic auditory verbal comprehension skills, as confirmed by the Aachen Aphasia Test; (6) diagnosis of post-stroke depression as per ICD-10 code F06.32

Exclusion criteria

Exclusion criteria: (1) other severe neurological disorders; (2) significant uncorrected visual or hearing disability; (3) severe nonverbal cognitive deficits, as revealed by the Corsi Block-Tapping Task; (4) simultaneous speech-language therapy or psychotherapy during the 3-week intervention phase

Design outcomes

Primary

Measure	Time frame
Feasibility, defined as at least 80% attendance during the intervention phase	—

Secondary

Measure	Time frame
(1) Symptoms of depression, assessed with a simplified version of the Beck Depression Inventory (BDI-V) and the Hamilton Rating Scale for Depression (HAM-D) (2) Verbal expression skills, assessed with the naming and word repetition subscale of the Aachen Aphasia Test (AAT) and the Amsterdam-Nijmegen Everyday Language Test (ANELT) (3) Psychological flexibility, assessed with the Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT) and the Scope-of-Action Index (SAI) (4) Inner speech ability, assessed in a verbal self-instruction paradigm (Simon Task)	—

Measure

Time frame

(1) Symptoms of depression, assessed with a simplified version of the Beck Depression Inventory (BDI-V) and the Hamilton Rating Scale for Depression (HAM-D) (2) Verbal expression skills, assessed with the naming and word repetition subscale of the Aachen Aphasia Test (AAT) and the Amsterdam-Nijmegen Everyday Language Test (ANELT) (3) Psychological flexibility, assessed with the Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT) and the Scope-of-Action Index (SAI) (4) Inner speech ability, assessed in a verbal self-instruction paradigm (Simon Task)

—

Countries

Germany

Contacts

Public ContactBenjamin Stahl

Medical School Berlin

benjamin.stahl@medicalschool-berlin.de030 7668 375 600

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026