Clonal hematopoiesis
Conditions
Interventions
Group 1: Persons with clonal hematopoiesis (CH)
Sponsors
Universität Leipzig, Medizinische Fakultät, Klinik und Poliklinik für Hämatologie, Zelltherapie und Hämostaseologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Signed informed consent - Presence of a somatic genetic alteration in blood cells or bone marrow, fulfilling the diagnostic criteria of clonal hematopoiesis as defined in the WHO classification of haematolymphoid tumours, 5 th edition, 2022 (for clarity: with or without accompanying cytopenia and irrespective of the method by which the alteration was detected).
Exclusion criteria
Exclusion criteria: - Confirmed diagnosis of a myeloid neoplasm (e.g. myelodysplastic neoplasia [MDS], myeloproliferative neoplasm [MPN], myelodysplastic/myeloproliferative neoplasm [MDS/MPN] or acute myeloid leukemia [AML]) before inclusion, as defined in the WHO classification of haematolymphoid tumours, 5 th edition, 2022. For clarity, for subjects with cytopenia or other abnormal lab results, a bone marrow examination is not mandatory before inclusion in this registry. - Cognitive, mental or other disorder, inability to read or understand German, or any other condition that renders the subject unable to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Descriptive dataset on epidemiology and spectrum of genetic alterations in individuals with clonal hematopoiesis | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival of persons with CH | — |
Countries
Germany
Contacts
Public ContactBeatrice Berneck
Universität Leipzig, Medizinische Fakultät, Klinik und Poliklinik für Hämatologie, Zelltherapie und Hämostaseologie
Outcome results
None listed