Skip to content

The Role of the µ-Opioid Receptor 1 A118G Nucleotide Polymorphism in the Context of Traumatic Childhood Events and Aggression

The Role of the µ-Opioid Receptor 1 A118G Nucleotide Polymorphism in the Context of Traumatic Childhood Events and Aggression - µ-Opioid-Rezeptor 1 Polymorphismus and Aggression

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00037634
Enrollment
160
Registered
2025-09-10
Start date
2025-10-01
Completion date
Unknown
Last updated
2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F10-F19

Interventions

Group 1: 80 to 160 forensic psychiatric patients undergoing treatment in a detoxification facility according to Section 64 of the German Penal Code (StGB). At the beginning of the study (time point 1

Sponsors

Universitätsklinikum Ulm, Klinik für Forensische Psychiatrie und Psychotherapie
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: sufficient knowledge of German

Exclusion criteria

Exclusion criteria: None; intellectual disability would be a criterion. However, since these are patients who are fully legally competent, this criterion is not to be expected.

Design outcomes

Primary

MeasureTime frame
The primary endpoint of the study is the statistical correlation between the results of the genetic analysis of µ-opioid receptor 1 A118G nucleotide polymorphisms and the self-report questionnaire results on traumatic childhood experiences and reactive/appetitive aggression, or impulsivity.

Secondary

MeasureTime frame
After a maximum of six and a half years, clarification is carried out regarding a potentially moderating relationship between the µ-opioid receptor 1 A118G nucleotide variants and successful forensic psychiatric therapy, based on documented therapy courses.

Countries

Germany

Contacts

Public ContactMichael Fritz

Universitätsklinik Ulm, Klinik für Forensische Psychiatrie und Psychotherapie

michael.fritz@bkh-guenzburg.de+49(0)82219625804

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026