metastatic adenocarcinoma or squamous cell carcinoma of the aerodigestive tract
Conditions
Interventions
Group 1: Upfront stereotactic body radiation therapy (SBRT) before the initiation of systemic therapy:
Patients assigned to upfront SBRT receive SBRT to all active extracranial tumor lesions before in
Sponsors
Universitätsklinikum Heidelberg, Radiologische Klinik, RadioOnkologie und Strahlentherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • histologically confirmed adenocarcinoma or squamous cell carcinoma of the aerodigestive tract with metastatic disease detected on imaging. Biopsy of metastatic disease is preferred but not required. • one to ten extracranial active tumor lesions on recent imaging • all relevant tumor lesions can be treated with radiotherapy based on the judgment of the treating radiation oncologist • initiation or change of systemic therapy is clinically indicated but has not yet started • ECOG 0/1 • age =18 years • able and willing to provide informed consent
Exclusion criteria
Exclusion criteria: • serious medical comorbidities precluding ablative radiotherapy • substantial overlap of disease sites with a previously treated radiation volume that precludes meeting dose constraints in a composite plan • malignant meningitis • pregnant or lactating individuals • patient’s refusal to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to compare PFS (18 months) between all groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| event-free survival, overall survival, new lesion-free survival | — |
Countries
Germany
Contacts
Public ContactThomas Held
Universitätsklinikum Heidelberg, Radiologische Klinik, RadioOnkologie und Strahlentherapie
Outcome results
None listed