C73
Conditions
Interventions
Group 1: Retrospective cohort: analysis of archived thyroid cancer tissue
Group 2: Prospective cohort: Analysis of newly obtained thyroid cancer tissue
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - All patients with a differentiated or medullary thyroid carcinoma - Availability of informed consent - Availability of tissue samples from the primary tumor
Exclusion criteria
Exclusion criteria: - Patients with an anaplastic thyroid carcinoma - Tissue samples exclusively from a recurrence or distant metastases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence and number of cervical lymph node metastases in relation to tumor budding. | — |
Secondary
| Measure | Time frame |
|---|---|
| The impact of tumor budding and other factors on additional endpoints: - Size of the primary tumor - High-risk/low-risk profiles - Type of primary surgery (hemithyroidectomy, total thyroidectomy, lymph node dissection) - Postoperative complications - Number and type of revision surgeries - Number and type of adjuvant therapies - Influence on preoperative diagnostics (fine needle aspiration, tumor markers) - Histopathological differences (perineural, vascular, and lymphatic invasion; presence of typical mutations) - Distant metastasis | — |
Countries
Germany
Contacts
Public ContactAndreas Spörlein
Universitätsklinikum Freiburg, Klinik für Hals-, Nasen- und Ohrenheilkunde
Outcome results
None listed