Interaction between body mass index and pulmonary ventilation distribution in obese patients during laparoscopic surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037567

Enrollment

Registered

2025-08-05

Start date

2025-08-11

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E66.0

Interventions

Group 1: Group BMI 40-49.9 kg/m2 To investigate the influence of positive end-expiratory pressure (PEEP) on end-expiratory lung impedance, pulmonary ventilation distribution, lung mechanics and volume

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Performance of a bariatric procedure at Mannheim University Hospital - Presence of grade 3 obesity (body mass index = 50kg/m2) - Consent to participate in the study

Exclusion criteria

Exclusion criteria: - Age < 18 years - Chronic lung diseases

Design outcomes

Primary

Measure	Time frame
Delta end-expiratory lung impedance (delta EELI) between different BMI groups and PEEP levels	—

Secondary

Measure	Time frame
- Delta end-expiratory lung impedance (delta EELI) between baseline general anesthesia (PEEP 8 cmH2O) and PEEP level with highest static compliance of the respiratory system - Delta EELI between different PEEP levels - Delta alveolar collapse between the start and end of the decremental PEEP trial (delta collapse PEEP 24-6 cmH2O) - Parameters of the pulmonary ventilation distribution - Ventilation parameters and pressures - Esophageal pressures and transpulmonary pressures - Lung mechanics - Gas exchange - Hemodynamics	—

Measure

Time frame

- Delta end-expiratory lung impedance (delta EELI) between baseline general anesthesia (PEEP 8 cmH2O) and PEEP level with highest static compliance of the respiratory system - Delta EELI between different PEEP levels - Delta alveolar collapse between the start and end of the decremental PEEP trial (delta collapse PEEP 24-6 cmH2O) - Parameters of the pulmonary ventilation distribution - Ventilation parameters and pressures - Esophageal pressures and transpulmonary pressures - Lung mechanics - Gas exchange - Hemodynamics

—

Countries

Germany

Contacts

Public ContactJörg Krebs

Universitätsmedizin Mannheim

Joerg.Krebs@umm.de+49 0621 383 3233

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026