postoperative organ dysfunction
Conditions
Interventions
Group 1: personalized perioperative blood pressure management
Group 2: standard of care
Sponsors
Klinikum der Universität München (LMU)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Study cohort of the DFG-funded IMPROVE study Patients undergoing major abdominal surgery who meet the following criteria: 45 years or older and additionally at least one of the following: Physical capacity of less than 4 METs (metabolic equivalents) Pre-existing kidney damage Coronary artery disease Heart failure Moderate or severe valvular heart disease History of stroke COPD or pulmonary fibrosis Medically managed diabetes mellitus Immunosuppression due to disease (e.g., HIV, leukemia, cancer) or medication Liver cirrhosis BMI of 30 kg/m² or higher Smoking history of 15 pack-years 65 years or older Anesthesia duration of at least 180 minutes BNP >200 ng/L within the last 6 months
Exclusion criteria
Exclusion criteria: History of organ transplantation, emergency surgeries, pregnancy, or (any type of) transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exploration of organ dysfunction-specific RNA, miRNAs and their target mRNAs, proteins, as well as functional outcomes (delirium, quality of life, clinical symptoms) in blood samples of patients of the Improve-multi study , sampling period between February 2023 and April 2024 | — |
Countries
Germany
Contacts
Public ContactAgnes Meidert
Klinikum der Universität München (LMU)
Outcome results
None listed