Gastric emptying and small intestine distribution in healthy subjects
Conditions
Interventions
Group 1: Ingestion of a manganese-labeled 10% glucose solution on an empty stomach and monitoring of gastric emptying and small intestine distribution using MRI.
Group 2: Ingestion of a manganese-labe
Sponsors
Universität Greifswald
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Age: 18–55 years old Gender: Male and female BMI: between 18 kg/m² and 30 kg/m² Good health, assessed by the investigator as not deviating from the norm in clinical terms. Written informed consent form available.
Exclusion criteria
Exclusion criteria: Disorders/diseases affecting the swallowing process (e.g., severe dysphagia related to food and/or solid oral dosage forms) Claustrophobia Gastrointestinal disorders and/or pathological changes that could interfere with gastric emptying Known or suspected stenosis, fistulas, or mechanical obstructions within the gastrointestinal tract Liver disorders Surgical procedures on the gastrointestinal tract within the last 12 months Inflammatory bowel diseases (Crohn's disease, ulcerative colitis, or diverticulitis) Implanted or portable electromechanical medical devices such as pacemakers, defibrillators, or infusion pumps Large dark tattoos Known allergies or intolerances to the components of the fluids Alcohol or drug addiction Smokers who consume more than 10 cigarettes per day Eating disorders such as anorexia or bulimia Positive pregnancy test or pregnancy People who are known to be unwilling or unable to follow instructions reliably Persons who are unable to understand written and verbal instructions and instructions regarding the risks of the study Less than 14 days after acute illness Systemic use of medication, especially medication that affects the function of the gastrointestinal tract Simultaneous participation in interventional research projects; the interval since previous participation in other studies should not be less than 14 days
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Training of an artificial intelligence for automated segmentation of the stomach and small intestine. | — |
Primary
| Measure | Time frame |
|---|---|
| Dependence of gastric emptying and small intestine distribution of a glucose solution in the fasting versus postprandial state. | — |
Countries
Germany
Contacts
Public ContactWerner Weitschies
Universität Greifswald
Outcome results
None listed