Multicenter, retrospective study on pre-surgical epilepsy diagnostics and surgical treatment of temporal meningoencephaloceles (MEZ)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037559

Enrollment

120

Registered

2025-08-12

Start date

2024-12-01

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G40

Interventions

Group 1: People with epilepsy due to a temporal meningoencephalocele who underwent pre-surgical video-EEG monitoring at one of the study centers

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Presence of epilepsy and MEZ, pre-surgical epilepsy diagnostics

Exclusion criteria

Exclusion criteria: Lack of sufficient clinical information

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the number of patients with a good outcome after epilepsy surgery for one or more temporal meningoencephaloceles (Engel Class I or IA). The target variable is a reduction in seizure frequency that meets the criteria for Engel Class I, meaning at least freedom from disabling seizures, or complete seizure freedom (Class IA). The primary endpoint is assessed based on information obtained from the patient or caregivers during routine clinical examinations.	—

Measure

Time frame

The primary endpoint is the number of patients with a good outcome after epilepsy surgery for one or more temporal meningoencephaloceles (Engel Class I or IA). The target variable is a reduction in seizure frequency that meets the criteria for Engel Class I, meaning at least freedom from disabling seizures, or complete seizure freedom (Class IA). The primary endpoint is assessed based on information obtained from the patient or caregivers during routine clinical examinations.

—

Secondary

Measure	Time frame
Extent of resection; postoperative results of neurological status, seizure frequency below Engel I level, neuropsychological performance, social participation and quality of life of patients.	—

Countries

Germany

Contacts

Public ContactJohann Philipp Zöllner

Universitätsmedizin Frankfurt am Main

zoellner@med.uni-frankfurt.de06963017466

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026