Aerosol measurement in children with SARS-CoV-2 and other respiratory infections - Determination of aerosol particle count and aerosol particle size distribution in the exhaled air of healthy children and children with respiratory infections, especially children with and after SARS-CoV2 infection

Aerosol measurement in children with SARS-CoV-2 and other respiratory infections - Determination of aerosol particle count and aerosol particle size distribution in the exhaled air of healthy children and children with respiratory infections, especially children with and after SARS-CoV2 infection - AEROSOL

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037533

Enrollment

150

Registered

2025-07-28

Start date

2024-08-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J06 A08

Interventions

Group 1: Measurement of aerosol particle size distribution in exhaled air and infection status in children aged 2–17 years with symptoms of respiratory infection or gastroenteritis Group 2: Measuremen

Eligibility

Sex/Gender

All

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Intervention group: - Acute respiratory infection - Acute SARS-CoV-2 infection - Acute gastroenteritis Control group - No symptoms of respiratory and/or gastrointestinal infection

Exclusion criteria

Exclusion criteria: - Age 17 years - Lack of consent from legal guardians or the participant - Chronic pre-existing cardiac, pulmonary, or allergic conditions - Malformations of the upper respiratory tract - Long-term medication (e.g., salbutamol, inhaled steroids)

Design outcomes

Primary

Measure	Time frame
The primary objective is to determine the aerosol concentration in exhaled air measured in particles/liter in children and adolescents with and without infections (including SARS-CoV-2). It is assumed that the aerosol concentration is 5-10 times higher in sick children and adolescents than in adults.	—

Secondary

Measure	Time frame
Secondary endpoints are - Age-dependent determination of the proportion of children and adolescents with elevated aerosol concentrations - Correlation of aerosol concentration with the viral load of SARS-CoV-2 and other viral pathogens using quantitative PCR. - Correlation of the detectability of various viral pathogens using qualitative PCR with aerosol concentration - Correlation of the qualitative detectability of viral pathogens in stool samples (PCR) with qualitative detectability in exhaled air using PCR	—

Measure

Time frame

Secondary endpoints are - Age-dependent determination of the proportion of children and adolescents with elevated aerosol concentrations - Correlation of aerosol concentration with the viral load of SARS-CoV-2 and other viral pathogens using quantitative PCR. - Correlation of the detectability of various viral pathogens using qualitative PCR with aerosol concentration - Correlation of the qualitative detectability of viral pathogens in stool samples (PCR) with qualitative detectability in exhaled air using PCR

—

Countries

Germany

Contacts

Public ContactFolke Brinkmann

Klinik für Kinder- und Jugendmedizin Bochum der Ruhr Universität Bochum

folke.brinkmann@uksh.de+49 234 509 2611

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026