Treatment effect of intermittent hypoxia-hyperoxia therapy (IHHT) on physical and cognitive performance in post-COVID patients

Treatment effect of intermittent hypoxia-hyperoxia therapy (IHHT) on physical and cognitive performance in post-COVID patients - IHHT

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037519

Enrollment

Registered

2025-07-25

Start date

2025-08-08

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

U09.9

Interventions

Group 1: Post-COVID patients receiving intermittent hypoxia-hyperoxia therapy. The questionnaires on post-COVID symptoms, medical history, and part of the clinical examination (6-minute walk test, 1-m

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. ability to give informed consent 2. post-COVID syndrome with fatigue and cognitive deficits 3. sufficient language skills to answer questionnaires

Exclusion criteria

Exclusion criteria: 1. unwillingness to participate/non-existence of consent 2. known sleep apnea 3. Insufficient language skills 4. Excessive mental and physical load 5. acute cerebrovascular diseases 6. acute forms of ischemic heart disease 7. cardiac insufficiency NYHA III-IV 8. COPD and bronchial asthma with significant shortness of breath (SpO2 > 90%)

Design outcomes

Primary

Measure	Time frame
Distance in the 6-minute walking test in meters. The distance that the test subjects can cover in 6 minutes is measured in meters. This is done before the start of the study and after the 6 weeks of IHHT. For the measurement, a measuring wheel was used to measure a distance of 30 meters, which was marked every 3 meters. At the start, the test subjects rest on a chair and then walk the distance at a pace appropriate to their physical condition for 6 minutes. The expectation is that the distance covered by the test subjects receiving the therapy will improve after 6 weeks.	—

Measure

Time frame

Distance in the 6-minute walking test in meters. The distance that the test subjects can cover in 6 minutes is measured in meters. This is done before the start of the study and after the 6 weeks of IHHT. For the measurement, a measuring wheel was used to measure a distance of 30 meters, which was marked every 3 meters. At the start, the test subjects rest on a chair and then walk the distance at a pace appropriate to their physical condition for 6 minutes. The expectation is that the distance covered by the test subjects receiving the therapy will improve after 6 weeks.

—

Secondary

Measure	Time frame
1. 1-minute sit-to-stand test 2. Fatigue Assessment Scale (FAS) 3. Montreal Cognitive Assessment (MoCa) 4. cognitive assessment with RehaCom 5. GAD-7 (generalized anxiety disorder scale) 6. PHQ-9 (patient questionnaire for depression) 7. VR-12 (questionnaire on health-related quality of life)	—

Countries

Germany

Contacts

Public ContactStefan Engeli

Institut für Pharmakologie, Universitätsmedizin Greifswald

stefan.engeli@med.uni-greifswald.de+49 3834 86 5633

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026