Multimodal Prehabilitation to Reduce Risk Prior to Oncologic Visceral Surgical Procedures

Multimodal Prehabilitation to Reduce Risk Prior to Oncologic Visceral Surgical Procedures - PPRIO

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037479

Enrollment

Registered

2025-11-20

Start date

2025-11-15

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal cancers (colon, pancreas, stomach) Sarcopenia and functional impairment in surgical oncology patients Preoperative risk stratification and recovery optimization

Interventions

Group 1: Multimodal Prehabilitation (single-cohort study) All enrolled patients receive standardized multimodal prehabilitation with no control group. The intervention includes: - daily moderate physi

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: Planned curative visceral-oncologic surgery (e.g. colorectal, gastric, pancreatic) Recruitment at least 7 days prior to scheduled surgery Age = 65 years Sufficient German language proficiency (for consent, intervention participation, questionnaires)

Exclusion criteria

Exclusion criteria: Cognitive impairment incompatible with program participation Decline of study participation Medical contraindications to physical activity or nutritional therapy

Design outcomes

Primary

Measure	Time frame
Primary endpoint: Feasibility of multimodal prehabilitation in routine clinical practice What: Proportion of enrolled patients who complete at least 70% of the recommended prehabilitation measures (exercise, nutrition, relaxation) during the entire prehabilitation period. Feasibility further includes completeness of data collection (diary + questionnaire) and adherence rate as quantifiable variables. When: Assessed throughout the prehabilitation phase from study inclusion until the day of surgery (minimum 7 days). How: Documentation via a standardized patient diary with daily recording of performed measures, and a standardized self-report questionnaire completed at hospital admission. Adherence (%) is calculated based on the number of days with documented implementation.	—

Measure

Time frame

Primary endpoint: Feasibility of multimodal prehabilitation in routine clinical practice What: Proportion of enrolled patients who complete at least 70% of the recommended prehabilitation measures (exercise, nutrition, relaxation) during the entire prehabilitation period. Feasibility further includes completeness of data collection (diary + questionnaire) and adherence rate as quantifiable variables. When: Assessed throughout the prehabilitation phase from study inclusion until the day of surgery (minimum 7 days). How: Documentation via a standardized patient diary with daily recording of performed measures, and a standardized self-report questionnaire completed at hospital admission. Adherence (%) is calculated based on the number of days with documented implementation.

—

Secondary

Measure	Time frame
1. Acceptance of the program, assessed through a short standardized patient survey 2. Barriers / facilitating factors in practical implementation (qualitative-descriptive) 3. Distress Thermometer (VAS) 4. NRS, handgrip strength measurement 5. Postoperative complication rate (according to the Clavien-Dindo classification, up to 30 days postoperatively) 6. Length of hospital stay (in days, from the day of surgery) a. Time to first mobilization on the ward (in days) b. Time to first bowel movement / stoma function after surgery (in days) c. Time in the intensive care unit (ICU) (in days)	—

Measure

Time frame

1. Acceptance of the program, assessed through a short standardized patient survey 2. Barriers / facilitating factors in practical implementation (qualitative-descriptive) 3. Distress Thermometer (VAS) 4. NRS, handgrip strength measurement 5. Postoperative complication rate (according to the Clavien-Dindo classification, up to 30 days postoperatively) 6. Length of hospital stay (in days, from the day of surgery) a. Time to first mobilization on the ward (in days) b. Time to first bowel movement / stoma function after surgery (in days) c. Time in the intensive care unit (ICU) (in days)

—

Countries

Germany

Contacts

Public ContactJens Schwarz

Klinikum Garmisch-Partenkirchen

jens.schwarz@klinikum-gap.de+49 8821777469

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026