Cardiac arrest
Conditions
Interventions
Group 1: Intervention Group (T-CPR):
Application of tourniquets to mechanically centralize blood volume (autotransfusion), in addition to all standard resuscitation measures according to current clini
Sponsors
Charité - Universitätsmedizin Berlin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Out-of-hospital cardiac arrest (OHCA) Persistent/refractory cardiac arrest upon arrival in the emergency department, despite guideline-conform prehospital resuscitation efforts Successful establishment of arterial access for invasive blood pressure monitoring in the emergency department No contraindications to tourniquet application on the extremities
Exclusion criteria
Exclusion criteria: Successful ROSC prior to randomization Known clinical or historical contraindications to tourniquet application (e.g., pre-existing severe peripheral arterial occlusive disease, amputations) Severe traumatic injuries to the extremities that preclude safe tourniquet placement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diastolic blood pressure during cardiopulmonary resuscitation | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with ROSC, defined as spontaneous and sustained pulse with measurable blood pressure for at least 20 minutes Neurological outcome at hospital discharge, assessed using the Cerebral Performance Category (CPC) score End-tidal CO2 during resuscitation Overall survival rate until hospital discharge Cumulative epinephrine dose administered during resuscitation Safety endpoints: occurrence of limb ischemia or other complications related to tourniquet application Vasopressor requirement during and immediately after resuscitation Lactate clearance during and after resuscitation | — |
Countries
Germany
Contacts
Public ContactJan Kruse
Charité Universitätsmedizin Berlin
Outcome results
None listed