Hypercapnic respiratory failure
Conditions
Interventions
Sponsors
Klinik für Anästhesiologie und Operative Intensivmedizin Universitätsklinikum Schleswig-Holstein, Campus Kiel
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients in intensive care units/ICU wards with hypercapnia (PaCO2 or PkapCO2 >45 mmHg) and clinical indication for non-invasive ventilation - Age over 18 years - Consent to study participation by the patient
Exclusion criteria
Exclusion criteria: - GCS < 14 - Lack of ability to give consent or communicate - Acute respiratory distress syndrome (ARDS) according to Berlin definition - Pulmonary fibrosis - Contraindications for non-invasive ventilation, such as facial injuries, upper airway obstructions, lack of protective reflexes, recurrent vomiting, ileus, allergies to mask or EIT belt components - PaO2/FiO2 ratio = 100 mmHg or SpO2/FiO2 ratio = 148 (with SpO2 = 97%) - Neither arterial access nor valid SpO2 measurement available - Thoracic injuries: unrelieved pneumothorax, open wounds of the thorax None of the above exclusion criteria may be met if a patient is to be included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient comfort (numeric rating scale) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Number of patients with = 2h NIV tolerance - Patient comfort (external assessment) - Leakage volume - ABG parameters: PaO2 or PkapO2, PaCO2 or PkapCO2, pH value - Regional ventilation distribution and change in end-expiratory lung volume, determined using electrical impedance tomography (EIT) - Vital parameters: Respiratory rate, heart rate, blood pressure, SpO2 - respiratory minute volume - mechanical power of ventilation | — |
Countries
Germany
Contacts
Public ContactTobias Becher
Klinik für Anästhesiologie und Operative Intensivmedizin Universitätsklinikum Schleswig-Holstein, Campus Kiel
Outcome results
None listed