The role of thalamic deep brain stimulation in action adaptation

The role of thalamic deep brain stimulation in action adaptation - TEMA

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037406

Enrollment

Registered

2025-07-11

Start date

2025-07-30

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F95.1 F95.2 G25.0

Interventions

Group 1: Participants with a diagnosis of tic disorder (F95.1, F95.2) who are undergoing treatment with deep brain stimulation (Percept PC or Percept RC) will be included in the study. Over the course

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patient cohort: The primary diagnosis is either a tic disorder (F95.1, F95.2) or essential tremor (G25.0) according to ICD-10 criteria. Treatment with deep brain stimulation (Percept PC or Percept RC neurostimulator). Participant cohort: no additional inclusion criteria.

Exclusion criteria

Exclusion criteria: Acute suicidality Severe psychiatric symptoms Severe internal (medical) comorbidities Severe neurological comorbidities or pre-existing conditions Substance dependence (excluding nicotine) Intellectual disability

Design outcomes

Primary

Measure	Time frame
Movement adaptation-related activity and connectivity between the sensorimotor cortex and thalamic electrodes in the beta frequency band (15–30 Hz).	—

Secondary

Measure	Time frame
Modulation of activity and connectivity profiles by deep brain stimulation.	—

Countries

Germany

Contacts

Public ContactTill Dembek

Uniklinik Köln, Klinik und Poliklinik für Neurologie

till.dembek@uk-koeln.de022147897602

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026