G35
Conditions
Interventions
Group 1: Comparison of the intrathecal cellular profile and cytokine profile of patients with primary
relapse-independent features to patients with primary relapse-related features and active relapsin
Sponsors
Medizinische Universität Wien Universitätsklinik für Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Treatment naïve patient with a clinical history or diagnosis of RRMS based on Radiological criteria (Thompson et al., 2018) No steroid use within the last 30 days Age =18 years Available brain MRI Planned lumbar puncture for diagnostic purposes Signed written declaration of consent
Exclusion criteria
Exclusion criteria: Age = 18 years No suspected diagnosis of MS No available MRI No planned lumbar puncture No consent Steroid treatment within the last 30 days Not treatment naive
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure the cellular and protein differences in the intrathecal compartment in patients showing pre-defined (radio-)pathological hallmarks. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare immune cell profiles and proteins of spinal fluid intra- and interindividual between cohorts. To evaluate the phenotype and transcriptional profiles of immune cell sub- populations in relation to disease activity monitored by MRI (New T2 lesions, T2 enlarging lesions, slowly evolving lesions, regional and general atrophy), OCT and clinical examinations (Expanded Disability Status Scale (EDSS) and to identify changes in clonal expansion and phenotype of the intrathecal B and T cell repertoire over time. | — |
Countries
Austria
Contacts
Public ContactTobias Zrzavy
Medizinische Universität Wien
Outcome results
None listed