surgical site infections
Conditions
Interventions
Group 1: Conventional, intermittent cefazolin application in the perioperative setting: In this group, cefazolin is applied conventionally, i.e. boluswise. The cefazolin concentrations in the EDTA pla
Sponsors
Universitätsklinikum Essen, Klinik für anästhesiologie und Intensivmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Elective surgery, planned duration >150 min
Exclusion criteria
Exclusion criteria: Emergency surgery, revision surgery, existing infection with already therapeutic antibiotic use, history of penicillin allergy (anaphylaxis, severe exanthema, shortness of breath) with the consequence of not using cephalosporins for antibiotic prophylaxis, acute or chronic kidney damage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative surgical site infections after neurosurgical or cardiac surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality, ventilation days, dialysis days, need for transfusion of blood or coagulation products, incidence of sepsis, length of stay in intensive care, length of hospital stay, need for postoperative antibiotic therapy, frequency of surgical wound revisions, pathogen spectrum of wound swabs | — |
Countries
Germany
Contacts
Public ContactJonas Gregorius
Universitätsklinikum Essen, Klinik für Anästhesiologie und Intensivmedizin
Outcome results
None listed