Hemodynamic effects of neurally adjusted ventilatory assist (NAVA) compared to conventional ventilation modes in children after cardiac surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037355

Enrollment

100

Registered

2025-09-02

Start date

2025-09-02

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q24.9

Interventions

Group 1: Comparison of neurally adjusted ventilatory assist (NAVA) with conventional ventilation modes, such as assisted and controlled ventilation, in terms of hemodynamic stability, improved cardiac

Eligibility

Sex/Gender

All

Age

No minimum to 16 Years

Inclusion criteria

Inclusion criteria: "All pediatric patients who require endotracheal intubation for more than 24 hours following cardiac surgery."

Exclusion criteria

Exclusion criteria: patients under muscle relaxation

Design outcomes

Primary

Measure	Time frame
Cardiac index (based on VTI, heart rate, and aortic diameter) Estimation of right ventricular pressure (via tricuspid regurgitation gradient + central venous pressure [CVP]) TAPSE (Tricuspid Annular Plane Systolic Excursion) Resistive Index (RI) in the anterior cerebral artery (ACA), renal artery, and blood flow in the celiac trunk Central venous pressure (CVP) and arteriovenous oxygen difference (avDO2) Near-infrared spectroscopy (NIRS) monitoring in the brain and kidneys Serum lactate levels	—

Measure

Time frame

Cardiac index (based on VTI, heart rate, and aortic diameter) Estimation of right ventricular pressure (via tricuspid regurgitation gradient + central venous pressure [CVP]) TAPSE (Tricuspid Annular Plane Systolic Excursion) Resistive Index (RI) in the anterior cerebral artery (ACA), renal artery, and blood flow in the celiac trunk Central venous pressure (CVP) and arteriovenous oxygen difference (avDO2) Near-infrared spectroscopy (NIRS) monitoring in the brain and kidneys Serum lactate levels

—

Secondary

Measure	Time frame
Vital signs: heart rate, blood pressure, oxygen saturation, respiratory rate Ventilation parameters: PEEP, PIP, MAP, oxygen requirement, dynamic compliance Sedation requirements (Comfort-B scale, SOS-PD scale) Catecholamine requirements Urine output (ml/kg/h)	—

Countries

Germany

Contacts

Public ContactSven Dittrich

Kinderkardiolgie Universitätsklinikum Erlangen

kinderkardiologie@uk-erlangen.de+4991318533750

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026