M34.0
Conditions
Interventions
Group 1: Adult patients with systemic sclerosis who underwent HRCT (High-resolution computed tomography) and had a concurrent dual-energy X-ray absorptiometry (DXA) scan available
Sponsors
Justus-Liebig-Universität Giessen, Campus Kerckhoff
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Confirmed diagnosis of systemic sclerosis according to the 2013 ACR/EULAR classification criteria Available HRCT of the thorax DXA scan performed within ±6 months of the HRCT examination
Exclusion criteria
Exclusion criteria: Missing HRCT or DXA scan, or a time interval between the two examinations exceeding ±6 months Anatomical or pathological alterations that could significantly distort bone density measurements by HRCT or DXA, such as severe degenerative spinal changes or osteolytic/osteoblastic lesions Presence of known secondary causes of osteoporosis (excluding SSc), including prolonged high-dose corticosteroid therapy (>7.5 mg prednisolone equivalent daily for more than 3 months), metabolic bone diseases (e.g., primary hyperparathyroidism, renal osteodystrophy), multiple myeloma, or severe endocrine disorders (e.g., untreated Cushing’s syndrome, untreated hypogonadism, uncontrolled diabetes mellitus) Inadequate image quality of HRCT or DXA Missing or incomplete patient data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between HU values from HRCT and BMD values from DXA Diagnostic agreement between HU-based and DXA-based osteoporosis classifications Determination of an optimal HU cutoff value for the identification of osteoporosis | — |
Secondary
| Measure | Time frame |
|---|---|
| Influence of clinical variables on HU values and BMD Reproducibility of HU measurement (interrater reliability) Association between low HU values and osteoporotic fractures | — |
Countries
Germany
Contacts
Public ContactNils Schulz
Justus-Liebig-Universität Giessen, Campus Kerckhoff
Outcome results
None listed