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German National Cohort (NAKO)

German National Cohort (NAKO) - NAKO

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00037328
Enrollment
200000
Registered
2025-09-11
Start date
2014-06-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In particular, common diseases such as cardiovascular diseases, cancer, diabetes and infectious diseases are investigated.

Interventions

Group 1: Every five years, 205,000 people aged between 20 and 69 from 16 study regions in Germany undergo comprehensive medical examinations and are asked about their lifestyle habits.

Sponsors

NAKO e.V.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 69 Years

Inclusion criteria

Inclusion criteria: The study base consisted of all persons in the age range 20 – 69 years (age at the time of sampling) residing within predefined study regions in the catchment areas of the study centers. Persons who lived in the predefined study regions at the time of sampling, but had moved out by the time of contact, could still participate in the study.

Exclusion criteria

Exclusion criteria: German citizenship was not required for participation, but German language skills (or a translator provided by the participant) were necessary to complete written informed consent, questionnaires and examinations.

Design outcomes

Primary

MeasureTime frame
Chronic diseases of the cardiovascular system and lungs, diabetes, cancer, dementia and depression

Secondary

MeasureTime frame
- Cardiovascular diseases o Heart attack, narrowing of the coronary arteries or angina pectoris o Heart failure or cardiac insufficiency o Cardiac arrhythmia o Intermittent claudication or circulatory disorder in the legs, also known as intermittent claudication or arterial occlusive disease o High blood pressure o Stroke o Thrombosis of the deep leg veins - Cancer - Metabolic diseases o Diabetes mellitus o Elevated blood lipids or cholesterol or triglycerides o Gout or uric acid disease o Thyroid disease - Diabetes mellitus Comorbidities o Retinopathy, i.e. damage to the retina o Blindness o Protein in urine o Kidney failure or restriction of o Kidney function o Treatment with an ‘artificial kidney’, i.e. o Dialysis or kidney transplant o Nerve disorders in the legs, e.g. numbness, burning, tingling o Amputations of e.g. toe, foot, lower leg or o Thigh o Diabetic foot (poorly healing Ulcer) - Musculoskeletal disorders o Chronic back pain o Osteoporosis o Osteoarthritis or joint wear o Rheumatic joint diseases o Carpal tunnel syndrome - Lung diseases o Chronic bronchitis or COPD o Bronchial asthma o Pulmonary emphysema o Pneumonia o Pulmonary embolism o Sleep apnoea - Allergies o Hay fever o Insect venom allergy (after being stung by a bee, wasp, bumblebee or hornet) o Food allergy o House dust allergy o Animal hair allergy o Contact allergy o Drug allergy o Other allergies - Gastrointestinal or liver diseases o Stomach ulcer or duodenal ulcer o Heartburn or reflux of stomach acid into the oesophagus o Chronic gastritis o Sprue o Irritable bowel syndrome o Inflammation of the pancreas o Fatty liver o Ulcerative colitis or Crohn's disease o Gallstones o Cirrhosis of the liver - Skin diseases o Neurodermatitis or atopic eczema o Psoriasis - Kidney diseases o Chronic renal insufficiency - Neurological and psychiatric illnesses o Depression o Alzheimer's disease, dementia o Stroke o Seizur

Countries

Germany

Contacts

Public ContactLinda Weißer

NAKO e.V.

geschaeftststelle@nako.de+496221426200

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026