N80
Conditions
Interventions
Group 1: Women aged 18 to 50 years with suspected or confirmed endometriosis (ICD-10 N80.x), scheduled for endometriosis-related or elective abdominal/pelvic surgery, who will be observed within the S
Sponsors
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie des Universitätsklinikums Münster
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Confirmed or suspected diagnosis of endometriosis according to ICD-10 code N80.x (including, for example, N80.0–N80.9) Planned surgical procedure, either: a. for the diagnosis or treatment of endometriosis (e.g., endometriosis excision), or b. an elective abdominal or pelvic surgery in patients with confirmed endometriosis Capacity to consent and provision of written informed consent Sufficient proficiency in German to understand and complete study questionnaires and digital assessment tools
Exclusion criteria
Exclusion criteria: Age under 18 or over 50 years; pregnancy or breastfeeding; lack of capacity to consent; cognitive impairment preventing completion of study questionnaires; insufficient German language skills to complete assessment tools; missing or refused written informed consent; preoperative blood draw is refused by the patient or is not possible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity (Numeric Rating Scale, NRS); pain-related functional impairment (Brief Pain Inventory, BPI); endometriosis-specific quality of life (Endometriosis Health Profile, EHP-30); pain characteristics (EPQ-S – Standard EPHect Questionnaire). | — |
Secondary
| Measure | Time frame |
|---|---|
| Menstrual and reproductive history (EPQ-S); medical and surgical history (EPQ-S); sociodemographic data (EPQ-S); pain sensitivity (Pain Sensitivity Questionnaire, PSQ-Minor); pain-related disability (Pain Disability Index, PDI); central sensitization (Central Sensitization Inventory, CSI); neuropathic pain features (DN4, NPSI); postoperative pain symptoms (modified Core Outcome Set for Endometriosis); psychological distress (Depression Anxiety Stress Scales, DASS-42); fatigue (Fatigue Scale for Motor and Cognitive Functions, FSMC); analgesic intake (manual documentation); opioid-related side effects (Opioid-Related Symptom Distress Scale, ORSDS); sensory function (bedside Quantitative Sensory Testing, QST); molecular biomarkers from blood, stool, and tissue (targeted and untargeted proteomics). | — |
Countries
Germany
Contacts
Public ContactEsther Pogatzki-Zahn
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie des Universitätsklinikums Münster
Outcome results
None listed