J09-J18
Conditions
Interventions
Group 1: Adults (=18 years) requiring intensive care with suspected pneumonia. Biomarker analysis of serum Arg9-Bradykinine will be collected at 4 different time points to determine the time course of
Sponsors
Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adults (=18 years) requiring intensive care with suspected pneumonia
Exclusion criteria
Exclusion criteria: Patients with pre-existing pneumonia (longer than 24 hours) at the time of admission/onset of illness. Patients with pre-existing chronic autoimmune disease (e.g., Crohn's disease, rheumatoid arthritis) at the time of admission/onset of illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The DABK plasma concentration at defined time points in patients with pneumonia in pg/ml. | — |
Secondary
| Measure | Time frame |
|---|---|
| Presence of organ failure (e.g., acute lung failure, kidney failure, multiple organ failure) based on the SOFA score. Examination of clinical inflammation parameters (e.g., IL-6, PCT, CRP) and their association with DABK. Assessment of intensive care measures (e.g., organ support). | — |
Countries
Germany
Contacts
Public ContactUlrike Heinicke
Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
Outcome results
None listed