Severe Inflammatory Response Syndrome, intestinal bacterial overgrowth
Conditions
Interventions
Group 1: Patients with cardiosurgical intervention under median sternotomy without the use of an extracorporeal circulation are asked before surgery for their microbiome-associated habits using a ques
Sponsors
Universitätsklinikum Tübingen
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - cardiac surgery with median sternotomy
Exclusion criteria
Exclusion criteria: - positive pregnancy test - heart failure (NYHA class III or higher) - peripheral arterial disease stage IIb or higher - chronic respiratory insufficiency requiring oxygen therapy - pharmacological immunosuppression - current treatment for malignancy - history of major intestinal surgery - chronic inflammatory bowel disease - dependency on / affiliation with the study team - vomiting and/or diarrhea within the past month (three or more episodes)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbial composition of stool before and after surgery by high-throughput microbiomics | — |
Secondary
| Measure | Time frame |
|---|---|
| - Duration of hsopital stay after surgery - Interactions of the microbiome within its community before and after surgery by high-throughput microbiomics - Concentration of bacterial metabolites in blood before and after surgery by gas-chromatography - Concentration of typical inflammation markers before and after surgery by standard laboratory analyses - Activity and nucleic acid expression patterns of immunocytes before and after surgery by RNA-analysis and single-cell sequencing - Incidence of clinical comorbidities before and after surgery | — |
Countries
Germany
Contacts
Public ContactPeter Rosenberger
Universitätsklinikum Tübingen
Outcome results
None listed