Sperm quality
Conditions
Interventions
Group 1: 30 participants take a multi-species probiotic once daily for 120 days.
Sponsors
Institut AllergoSan Deutschland (privat) GmbH
Eligibility
Sex/Gender
Male
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with diagnosed pathospermia The ability to begin taking the study medication promptly after inclusion in the study Signed informed consent form
Exclusion criteria
Exclusion criteria: Use of antibiotics within the last 4 weeks Use of probiotics within the last 4 weeks Intake of explicitly fertility-enhancing supplements within the last 4 weeks Regular or repeated use of medications known to impair spermatogenesis (according to the package insert) Severe impairment of semen quality: Oligo-Astheno-Teratozoospermia (OAT) grade III, pronounced parvisemia with an ejaculate volume < 1 ml Diagnosed gastrointestinal diseases (e.g., Crohn’s disease, ulcerative colitis) that could impair absorption of the study medication Congenital or acquired conditions (e.g., diabetes mellitus) or malformations (e.g., Klinefelter syndrome) that affect spermatogenesis Immunocompromised individuals Internally diagnosed conditions requiring medical treatment (e.g., cancer, liver dysfunction, severe heart disease) Necessity to take antibiotics during the intervention phase
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathospermia defined by: Volume of ejaculate (in ml), Density – sperm concentration per ml, Motility (in percent): a) progressively motile b) forward motile c) non-progressive d) immotile, Morphology – percentage of normally shaped sperm cells. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in the seminal microbiome (comparison between T0 and T1), change in hormone production across the three measurement time points: •Total testosteron ng/ml, •Total testosterone ng/ml, • estradiol pg/ml, • Sex hormone-binding globulin nmol/l, • Follicle stimulating hormone mIU/ml, • luteinizing hormone mIU/ml and • Prolactin µg/l • Albumin g/dl | — |
Countries
Germany
Contacts
Public ContactTobias Jäger
Urologische Praxisklinik Essen
Outcome results
None listed