Chronic painful fat distribution disorder E88.20-E88.22
Conditions
Interventions
Group 1: Patients with lipedema and moderately overweight (BMI 30 - 40).
One-time performance of QST according to the DFNS protocol (Rolke et al., 2006) as well as assessment of the German Pain Questi
Sponsors
Uniklinik Köln
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Present signed and irrevocable declaration of consent For lipedema patients: - Medical diagnosis of lipoedema - BMI > 30 kg/m2 and 30 kg/m2 and < 40 kg/m2
Exclusion criteria
Exclusion criteria: - Restriction of the ability to communicate (language barrier, cognitive barriers, dementia-related changes, ...) - Diseases that affect the sensory nervous system (e.g. Parkinson's disease, multiple sclerosis, radiculopathy, injuries to nerves innervating the measurement area of various origins, peripheral polyneuropathies of various origins, diabetes mellitus, ...) - Skin stress on the measurement areas (e.g. psoriasis) - topical application of analgesics to the measurement areas (e.g. plasters, creams, ...) - Other known change in pain perception or another diagnosed pain disorder - Diagnosed depression - Liposuction already performed prior to study inclusion - Pregnancy and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterization of the changes in the different sensory modalities in lipedema patients with moderate obesity compared to control subjects of the same body size using one-time quantitative sensory testing (QST) according to the protocol of the German Research Association on Neuropathic Pain. Which modalities are altered? Recording of pain-relevant self-report-based aspects such as intensity and variability of the pain experience as well as psychosocial aspects such as stress, depression, restrictions in everyday life, etc. assessed by the German Pain Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the quantitative sensory measurement with pain measurements commonly used in everyday clinical practice, such as the pain questionnaire of the German Pain Society. Does the strength of the change correlate with the variables recorded by the questionnaire, such as pain intensity, depression or restriction of everyday life? | — |
Countries
Germany
Contacts
Public ContactTim Hucho
Translationale Schmerzforschung
Outcome results
None listed